Importance Of Branched-Chain Amino Acids In Accelerating Recovery Along With Physiotherapeutic Interventions For Musculoskeletal Injuries
Abstract views: 55
/
PDF downloads: 116
DOI:
https://doi.org/10.61705/rbwqb654Abstract
Musculoskeletal injuries are predominant contributor to global disability, often requiring prolonged physiotherapeutic interventions for functional restoration. Nutritional support, particularly amino acid supplementation, serves a crucial function in repairing tissues and restoring muscles. Branched-Chain Amino Acids (BCAAs) leucine, isoleucine, and valine have garnered interest for their anabolic and restoring effects on musculoskeletal system. This article explores the role of BCAAs in enhancing recovery outcomes when integrated with physiotherapy for musculoskeletal injuries. Current evidence suggest that BCAA supplementation might promote muscle protein synthesis, reduce exercise-induced muscle damage, and improve rehabilitation efficiency, particularly when combined with structured physiotherapeutic exercise programs.
Downloads
References
Brower RG. Consequences of bed rest. Crit Care Med. 2009 Oct;37(10 Suppl):S422-8.
Cameron MH. Physical agents in rehabilitation: from research to practice. 4th ed. St. Louis (MO): Elsevier Health Sciences; 2013.
Cuthbertson DP. The disturbance of metabolism produced by bony and non-bony injury, with notes on certain abnormal conditions of bone. Biochem J. 1930;24(4):1244-63.
Duan Y, Li F, Li Y, Tang Y, Kong X, Feng Z, Anthony TG, Watford M, Hou Y, Wu G, Yin Y. The role of leucine and its metabolites in protein and energy metabolism. Amino Acids. 2016 Jan;48(1):41-51.
Hasselgren PO, Pedersen P, Sax HC, Warner BW, Fischer JE. Current concepts of protein turnover and amino acid transport in liver and skeletal muscle during sepsis. Arch Surg. 1988;123(8):992-9.
Ikeda T, Jinno T, Masuda T, Aizawa J, Ninomiya K, Suzuki K, Hirakawa K. Effect of exercise therapy combined with branched-chain amino acid supplementation on muscle strengthening in persons with osteoarthritis. Hong Kong Physiother J. 2018;38(1):23-31.
Jackman SR, Witard OC, Philp A, Wallis GA, Baar K, Tipton KD. Branched-Chain Amino Acid Ingestion Stimulates Muscle Myofibrillar Protein Synthesis following Resistance Exercise in Humans. Front Physiol. 2017 Jun 7;8:390.
Long CL, Jeevanandam M, Kim BM, Kinney JM. Whole body protein synthesis and catabolism in septic man. Am J Clin Nutr. 1977 Aug;30(8):1340-4.
Moriwaki M, Wakabayashi H, Sakata K, Domen K. The effect of branched chain amino acids-enriched nutritional supplements on activities of daily living and muscle mass in inpatients with gait impairments: A randomized controlled trial. J Nutr Health Aging. 2019;23(4):348-53.
Nie C, He T, Zhang W, Zhang G, Ma X. Branched Chain Amino Acids: Beyond Nutrition Metabolism. Int J Mol Sci. 2018 Mar 23;19(4):954.
Patel DR, Yamasaki A, Brown K. Epidemiology of sports-related musculoskeletal injuries in young athletes in United States. Transl Pediatr. 2017 Jul;6(3):160-166.
Shimomura Y, Inaguma A, Watanabe S, Yamamoto Y, Muramatsu Y, Bajotto G, Sato J, Shimomura N, Kobayashi H, Mawatari K. Branched-chain amino acid supplementation before squat exercise and delayed-onset muscle soreness. Int J Sport Nutr Exerc Metab. 2010 Jun;20(3):236-44.
Smith-Ryan AE, Hirsch KR, Saylor HE, Gould LM, Blue MN. Nutritional considerations and strategies to facilitate injury recovery and rehabilitation. J Athl Train. 2020;55(9):918-30.
Takeuchi I, Yoshimura Y, Shimazu S, Jeong S, Yamaga M, Koga H. Effects of branched-chain amino acids and vitamin D supplementation on physical function, muscle mass and strength, and nutritional status in sarcopenic older adults undergoing hospital-based rehabilitation: A multicenter randomized controlled trial. Geriatr Gerontol Int. 2019;19(1):12-7.
VanDusseldorp TA, Escobar KA, Johnson KE, Stratton MT, Moriarty T, Cole N, McCormick JJ, Kerksick CM, Vaughan RA, Dokladny K, Kravitz L, Mermier CM. Effect of Branched-Chain Amino Acid Supplementation on Recovery Following Acute Eccentric Exercise. Nutrients. 2018 Oct 1;10(10):1389.
Williamson DH, Farrell R, Kerr A, Smith R. Muscle-protein catabolism after injury in man, as measured by urinary excretion of 3-methylhistidine. Clin Sci Mol Med. 1977 May;52(5):527-33.
Wolfe RR. Branched-chain amino acids and muscle protein synthesis in humans: myth or reality? J Int Soc Sports Nutr. 2017 Aug 22;14:30.
Zhai G. Alteration of metabolic pathways in osteoarthritis. Metabolites. 2019;9(1):11.
Additional Files
Published
Issue
Section
License
Copyright (c) 2022 International Journal of Medical Research

This work is licensed under a Creative Commons Attribution 4.0 International License.
All papers should be submitted electronically. All submitted manuscripts must be original work that is not under submission at another journal or under consideration for publication in another form, such as a monograph or chapter of a book. Authors of submitted papers are obligated not to submit their paper for publication elsewhere until an editorial decision is rendered on their submission. Further, authors of accepted papers are prohibited from publishing the results in other publications that appear before the paper is published in the Journal unless they receive approval for doing so from the Editor-In-Chief.
IJMR open access articles are licensed under a Creative Commons Attribution-ShareAlike 4.0 International License. This license lets the audience to give appropriate credit, provide a link to the license, and indicate if changes were made and if they remix, transform, or build upon the material, they must distribute contributions under the same license as the original.
