EVALUATION OF THE IMPACT OF SENNA ALATA ON LIPID PROFILE LEVELS IN ALLOXAN-INDUCED DIABETIC WISTAR RATS
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DOI:
https://doi.org/10.61705/1aq4w740Keywords:
Senna alata, total cholesterol, high-density lipoproteins, low-density lipoproteinsAbstract
Diabetes is a metabolic condition where the body either fails to produce sufficient insulin or becomes resistant to its effects, resulting in high blood sugar levels. This disorder can lead to serious health problems, including stroke, kidney failure, blindness, amputations, cardiovascular diseases, and birth defects. The aim of this research was to investigate the impact of Senna alata on serum levels of total cholesterol, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) in Wistar rats with diabetes induced by alloxan.
The study involved 50 albino rats, each weighing between 150 and 200 grams, and all were treated following ethical guidelines for animal research. The rats were given standard food and water and were divided into two main groups: a control group and an experimental group. The experimental group was further subdivided into five smaller groups, each consisting of 10 rats (Groups A-E). Group A served as the control, while Group B received 5.17 mg/kg of Senna alata aqueous extract, Group C received 15.40 mg/kg, Group D received 27.87 mg/kg, and Group E was administered 0.5 ml of distilled water without the extract. At the end of the treatment period, the rats were euthanized, and blood samples were taken for analysis of total cholesterol, HDL, and LDL levels using established laboratory techniques.
The results indicated both the mean and standard deviation values for the control and experimental groups. In the control group, total cholesterol (TC) was 79.85±31.61 mg/dl, while the experimental group showed a value of 87.46±39.99 mg/dl. Triglycerides (TG) in the control group were 56.57±19.37 mg/dl, compared to 105.53±73.42 mg/dl in the experimental group. LDL levels in the control group were 35.71±28.58 mg/dl, and in the experimental group, they were 57.46±36.07 mg/dl. No significant difference (p≥0.05) was found in the total cholesterol and LDL levels between the two groups. However, a statistically significant difference (p≤0.05) was observed in the triglyceride levels.
Conclusively, this study indicates that S. alata extracts do not exhibit anti-lipemic properties and do not reverse biochemical disruptions in diabetic rats. Therefore, S. alata is not suitable for preventing or treating hyperlipidemia.
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