THE HISTOLOGICAL EFFECTS OF ALLIGATOR ON THE UTERUS OF WISTAR RATS
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https://doi.org/10.61705/h5nwkq53Keywords:
Aframomum melegueta (alligator pepper), uterine histopathology, hyperplasia, carcinoma, Wistar rats, herbal medicine, antimicrobialAbstract
Aframomum melegueta (Alligator pepper), a member of the Zingiberaceae family, is a widely used spice with potential antimicrobial and therapeutic properties. The seeds of this plant are rich in phenolic compounds, which have been traditionally utilized in treating infections. This study aimed to evaluate the histopathological effects of aqueous extracts of Aframomum melegueta on the uterus of female Wistar rats. Fifty rats were divided into five groups (A-E), with Group A serving as the control and Groups B-E receiving increasing doses of aqueous A. melegueta extract (100, 200, 300, and 400 mg/kg, respectively) over a 14-day period. The rats' body weights were measured before and after treatment, with no significant weight changes observed across the groups. Histological analysis of uterine tissues showed normal architecture in the control group (Group A), while varying degrees of uterine abnormalities were observed in the treatment groups. Group B (100 mg/kg) exhibited clear cell carcinoma in the endometrium, while Groups C (200 mg/kg) and D (300 mg/kg) showed endometrial hyperplasia. Group E (400 mg/kg) displayed findings consistent with adenomyosis. These results suggest that moderate to high doses of A. melegueta may induce severe histopathological changes in the uterus, including neoplastic and hyperplastic alterations, without affecting body weight. Further research is needed to elucidate the mechanisms underlying these effects and to assess the long-term safety of Aframomum melegueta consumption.
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